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Mixing Alcohol & Pills

Can Mixing Alcohol and Pills Kill You?

Alcohol is a central nervous system depressant that slows breathing and heart rate. Combining alcohol with other drugs, especially other central nervous system depressants is extremely dangerous. If you're wondering whether or not combining alcohol and Benadryl or another common drug can kill you, the answer may surprise you.

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Mixing Alcohol and Benadryl

Benadryl is a common over-the-counter medicine used in the treatment of allergies, congestion and the common cold. It is also sometimes used for motion sickness.

Benadryl, which is also known as diphenhydramine in its generic form, is an acetylcholine and histamine blocker (antihistamine). The body produces these substances during illness, which result in nasal congestion, watery eyes and other symptoms usually associated with allergy.

Common side effects of Benadryl include drowsiness and dizziness, dry nasal and bronchial passages, upset stomach, blurry vision and constipation. These side effects occur even when used precisely as directed and without alcohol.

Benadryl's active ingredients slow down the body just as alcohol does. Combining Benadryl with alcohol or with another central nervous system depressant, such as a painkiller or benzodiazepine is extremely dangerous and can kill you.


Used in the treatment of allergies, congestion and the common cold. It is also sometimes used for motion sickness.

Benadryl + Alcohol

Profound dizziness and drowsiness & Possible death

What happens when you mix Alcohol with Xanax?

Xanax, also known as alprazolam, is a highly addictive benzodiazepine. Benzodiazepines are central nervous system depressants that are used for the relief of anxiety, sleeplessness, seizures and panic disorder.

Like alcohol, Xanax works on the GABA receptors in the human brain to produce feelings of relaxation. People who have a legitimate prescription for a drug such as Xanax should never use the drug regularly for an extended period of time, unless under the explicit instructions of a qualified physician. Withdrawing from Xanax is extremely difficult after long-term use, even for those who take the drug exactly as prescribed.

Safe use dictates never combining a benzo with alcohol because the cumulative combined effects can be fatal. Both substances slow heart rate and breathing, and overdose is possible even in small amounts.

Never take Xanax if you have not been given a prescription for a legitimate medical need. Most who overdose from prescription drugs do so because they took a drug given to them by a friend or family member. Taking alcohol and Xanax together can kill you.


Used for the relief of anxiety, sleeplessness, seizures and panic disorder.

Xanax + Alcohol

Extreme slowing of heart rate and breathing & Possible death

Mixing Alcohol and Ibuprofen

Ibuprofen, commonly known by the brand names Advil, Motrin, and Midol is one of the most common and popular painkillers and anti-inflammatory drugs in the world. Can taking alcohol and ibuprofen kill you? Absolutely but perhaps not for the reason you think.

Ibuprofen, despite its undeniable efficacy at treating minor to moderate pain, is well known to cause problems in the liver. Alcohol also damages the liver, especially when heavy drinking occurs over a lengthy period of time.

Never take ibuprofen as a remedy for drinking you’ll damage your internal organs. From bleeding stomach ulcers to liver failure, ibuprofen and alcohol together is a deadly mix.


Used for the treating minor to moderate pain and inflammation.

Ibuprofen + Alcohol

Internal organ damage, including stomach ulcers and liver failure & Possible death

Mixing Alcohol with Paracetamol (Tylenol)

Paracetamol, a drug more widely known in America as acetaminophen or Tylenol, is toxic to the liver during overdose. In fact people who suffer from acute liver failure usually have taken too much acetaminophen. Nausea and abdominal pain are common side effects of paracetamol toxicity, which can be fatal if not treated.

It is important to note that paracetamol is safe and effective when used precisely as directed and for a short period of time. Combining paracetamol and alcohol, however, can kill you because alcohol increases the toxicity of this otherwise safe and effective drug.


Used for the treating mild to moderate pain and to reduce fever.

Tylenol + Alcohol

Extreme nausea and abdominal pain along with liver failure & Possible death

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Can you mix Vicodin and Alcohol?

Vicodin is a powerful combination painkiller that is the most commonly prescribed opioid analgesic in America. Vicodin is a blend of the addictive opioid painkiller hydrocodone and the over-the-counter drug acetaminophen, which is also known as paracetamol or Tylenol.

Although the hydrocodone component of Vicodin is the addictive central nervous system depressant, Tylenol is toxic to the liver in large doses. In fact many who overdose on Vicodin do so because of acute liver toxicity.

Combining alcohol and Vicodin is dangerous. These two drugs account for more emergency room overdose visits than any other substances. Not only does alcohol enhance the relaxing effects of the hydrocodone, it also boosts the risk of developing liver problems. Overdosing on alcohol and Vicodin can kill you.


Used for the treating moderate to severe pain.

Vicodin + Alcohol

Extreme slowing (or complete stop) of heart rate and breathing & Possible death

Mixing Alcohol with Valium

Valium, also known as diazepam, is the most commonly prescribed benzodiazepine in the world. It is used in clinical settings to induce relaxation and treat anxiety. It is highly addictive and works in the central nervous system in a similar way to alcohol.

Taking Valium for a prolonged period of time is dangerous. Quitting suddenly can result in benzodiazepine withdrawal syndrome, an extremely uncomfortable condition that produces a variety of unpleasant physical and emotional effects.

Valium also produces physical dependency and tolerance. When combined with alcohol, a fatal overdose can result.


Used to induce relaxation and for treating anxiety and muscle spasms.

Valium + Alcohol

Profound dizziness and drowsiness, Extreme slowing of heart rate and breathing & Possible death

Mixing Alcohol and Moon Rocks

As a purer form of MDMA, moon rocks interact strongly and unpredictably with alcohol. Since MDMA is an amphetamine, moon rocks stimulate users and prevent them from realizing how intoxicated they really are, which can lead to excessive drinking and alcohol poisoning.

Mixing alcohol and moon rocks also makes users think they can drive a vehicle, since they don’t feel drunk, either physically or mentally. The powerfully stimulating properties of moon rocks suppress alcohol’s sedative effects while increasing its stimulating influence on the central nervous system. Heart palpitations, hyperventilation, hallucinations and shock are other potential health issues arising from mixing alcohol and moon rocks.

Moon Rocks

A designer drug derived from MDMA, purer in content than Molly or Ecstasy.

Moon Rocks + Alcohol

Tachycardia, difficulty breathing, alcohol poisoning and hallucinations.

Mixing Vyvanse and Alcohol

Vyvanse is a powerful stimulant prescribed to people with ADHD. Mixing alcohol with Vyvanse, or any other stimulant, causes an overshadowing of alcohol’s depressant effects so that you may not realize just how intoxicated you are.

Alcohol poisoning due to drinking excessively is a major concern, along with suffering heightened side effects of Vyvanse: Rapid heartbeat, difficulty breathing, elevated blood pressure, unpredictable changes in behavior and hallucinations. Signs of possible alcohol poisoning include uncontrollable vomiting, stupor, hypothermia and seizures.


A prescription stimulant designed to reduce symptoms of ADHD.

Vyvanse + Alcohol

Irregular heartbeat, hyperventilation, hallucinations and alcohol poisoning.

What happens when you mix Alcohol with BHO?

Butane hash oil (BHO) is concentrated marijuana plant resin, and an almost pure extract of THC, the ingredient in marijuana primarily responsible for its psychoactive properties. Mixing alcohol and BHO means users will experience alcohol’s intoxicating effects — the powerful mood, consciousness and perception-distorting properties of THC — along with the dangers associated with inhaling the butane left on the hash oil.

While butane will increase your heart and respiration rate, induce vomiting and cause dizziness, the pureness of BHO combined with alcohol’s ability to suppress central nervous system functioning can lead to overwhelming feelings of paranoia, anxiety and agitation that could last for several days.

Butane Hash Oil (BHO)

A particularly potent form of THC made by soaking marijuana leaves, stems and flowers in butane to extract pure THC.

BHO + Alcohol

Rapid heartbeat, difficulty breathing, anxiety, panic, paranoia and uncontrollable vomiting.

Mixing Alcohol and Pseudophedrine

Found in many over-the-counter allergy and cold medications, pseudophedrine reduces nasal congestion by constricting blood vessels in the sinuses and decreasing mucus production. Considered a mild stimulant, pseudophedrine counteracts alcohol’s sedative effects.

Consequently, mixing alcohol with pseudophedrine puts you at risk for alcohol poisoning or overdosing on cold medications, since alcohol and pseudophedrine counteract each other’s side effects on the central nervous system. Additional dangers of taking pseudophedrine and alcohol together include nausea, vomiting, irregular heartbeat, anxiety, tremors and spiking blood pressure.


A mildly stimulating ingredient found in cold and allergy medications for reducing nasal congestion.

Pseudophedrine + Alcohol

Overdosing on cold medications, alcohol poisoning, tachycardia, trouble breathing, abnormally high blood pressure.

Mixing Alcohol and Heroin

A powerfully addictive opiate producing analgesic and euphoric effects, heroin suppresses breathing, heart rate and other essential life functions controlled by the central nervous system. Mixing alcohol and heroin quickly and profoundly intensifies the sedative effects of heroin that can easily lead to alcohol poisoning or accidental overdose.

Shallow breathing, irregular heartbeat, tremors and loss of consciousness often occur when you mix heroin with alcohol. Since heroin is already a dangerously unpredictable drug that may be laced with toxic chemicals, drinking alcohol while high on heroin may cause sudden and deadly health conditions.


An addictive opiate causing extreme drowsiness, euphoria, slowed breathing, periods of alertness and unconsciousness.

Heroin + Alcohol

Dangerously slow breathing and heart rates, vomiting, shock, alcohol poisoning and even death.

Is it ok to mix Alcohol with Marijuana?

Using marijuana and alcohol together makes it more likely you will use too much of both substances. Since pot and alcohol are depressants, you won’t feel as “stoned” or drunk when combining them, as opposed to using one or the other alone. In addition, marijuana is an antiemetic, or a drug that seems to inhibit vomiting.

While drinking excessively usually causes most people to throw up, smoking pot while drinking means you’re much more susceptible to suffering alcohol poisoning, a condition that kills thousands of people every year. Studies have also shown that alcohol facilitates absorption of THC. Panic attacks, paranoia, delusions and agitation are likely if you smoke several grams of marijuana while drinking alcohol. Finally, mixing alcohol and marijuana can suppress breathing and heart rates to the point of inducing shock, unconsciousness and even coma.


A psychoactive plant containing THC that interferes with breathing and heart rates, impairs memory and decision-making and may cause paranoia and hallucinations.

Marijuana + Alcohol

Significantly increases the risk of alcohol poisoning, coma or suffering psychotic symptoms such as paranoia, delusions and hallucinations.

Can You Mix Alcohol and Antibiotics?

If you're taking a prescription drug such as amoxicillin, you may be wondering if mixing alcohol and an antibiotic can kill you. The answer depends on the drug you've been prescribed.

In general antibiotics can cause similar reactions to alcohol, even when taken exactly as prescribed. Drowsiness, dizziness and stomach upset can result when combining the two substances. Although some antibiotics may be safe to combine with alcohol, keep in mind that drinking can reduce the efficacy of the drug.

Other drugs, such as Flagyl, Tindamax and Bactrim, can cause a severe reaction when mixed with alcohol. These reactions include headache, severe gastrointestinal upset, an uncomfortably rapid heart rate and skin flushing. Avoid blending alcohol and antibiotics to eliminate the risk that an uncomfortable reaction will result.


Used for treating infections caused by bacteria.

Antibiotics + Alcohol

Profound dizziness, drowsiness and abdominal pain.

Staying Safe

Did you know most who overdose on prescription medication do so after getting it from a friend or relative? The latest evidence indicates people who take addictive drugs recreationally are more likely to suffer a fatal overdose than those who suffer from physical dependency. Mixing prescription pills and alcohol — and even mixing an over-the-counter drug such as ibuprofen or Benadryl is even deadlier.

The bottom line is it isn't safe to mix any drug with alcohol. If you combine drugs and alcohol to intensify the high and you can't seem to stop using, the time to get help is now.

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